Selective targeting of DNA for cleavage within DNA-histone assemblies by a spermine-[CpW(CO)3Ph]2 conjugate.
نویسندگان
چکیده
In contrast to the histone-modifying action of other complexes of the type CpML(n)R, the compound obtained by linking the phenyl rings of two CpW(CO)(3)Ph moieties to the DNA-binding agent spermine selectively cleaves DNA in DNA-histone assemblies.
منابع مشابه
Photoinduced DNA cleavage by cyclopentadienyl metal complexes conjugated to DNA recognition elements.
[structure: see text]. DNA recognition elements have been attached to CpW(CO)3CH3 and CpW(CO)3Ph, which produce methyl and phenyl radicals that cleave DNA upon photolysis. The inclusion of binding moieties in 3 increases the efficiency but not the selectivity of strand scission over that seen in the simple unfunctionalized complex, while 11 cleaves preferentially at T sites within AT-rich tracts.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 3 17 شماره
صفحات -
تاریخ انتشار 2005